Biochemical effects of riluzole on Leishmania parasites

► Riluzole (6-(trifluoromethoxy)benzothiazol-2-amine) affects Leishmania spp. ► Riluzole shows a cytotoxic activity on Leishmania parasites in vitro. ► Pteridine-reductase 1 (PTR1) is a target of riluzole. ► Riluzole impairs the oxidative stress resistance of Leishmania.