Isothermal microcalorimetry to study the activity of triclabendazole and its metabolites on juvenile and adult Fasciola hepatica

► Isothermal microcalorimetry is useful to document drug effects on juvenile Fasciola hepatica. ► Triclabendazole and its metabolites impact the motor activity of F. hepatica. ► Limitations of calorimetric measurements were observed using adult F. hepatica.