Effect of antimicrobial peptides derived from human cathelicidin LL-37 on Entamoeba histolytica trophozoites

► LL-37 affects the integrity and growth of Entamoeba trophozoites. ► KR-12, KR-20 and KS-30 peptides derived from LL-37 were tested on E. histolytica. ► Human cathelicidin-derived peptides affect the viability of Entamoeba histolytica. ► Entamoeba histolytica cysteine proteases digest KR-12, KR-20, KS-30 and LL-37. ► LL-37 and KR-12, the shortest peptide tested, were less effective against ameba.