Emodepside and SL0-1 potassium channels: A review

► Emodepside is a broad spectrum cyclooctadepsipeptide anthelmintic drug. ► It has a mode of action different from the other classical groups of anthelmintics. ► We review its mode of action that show it inhibits neuronal and muscle activity. ► Rescue experiments suggest emodepside opens nematode Ca-dependent SLO-1 K channels. ► Its slow time-dependent action suggests it does not act in the extracellular domain of these channel.