Schistosoma mansoni: In vitro schistosomicidal activity and tegumental alterations induced by piplartine on schistosomula

► Piplartine is able to kill Schistosoma mansoni schistosomula of different ages. ► The lethal effect occurred in a dose-dependent manner and was also dependent on the age of the parasite. ► Confocal microscopy observation revealed that piplartine induced morphological changes on the tegument of the worms. ► Piplartine is a promising compound that could be used for the development of new schistosomicidal agent.