Encephalitozoonosis in pharmacologically immunosuppressed mice

► CD19+ B, CD3+ T, CD4+ T and CD8+ T cell in Cyclophosphamide-treated animals decreased significantly. ► Cyclosporin-immunosuppressed mice have a significant reduction of CD3+ T and CD4+ T lymphocytes. ► Cyclophosphamide-immunosuppressed mice have acute disseminated and fatal encephalitozoonosis. ► Ciclosporin treated mice had a milder, chronic non-lethal experimental infection.