The use of pentoxifylline as adjuvant therapy with praziquantel downregulates profibrogenic cytokines, collagen deposition and oxidative stress in experimental schistosomiasis mansoni

► Schistosoma mansoni infection increase cytokines, oxidative stress, liver collagen in mice. ► Non invasive markers confirm the antifibrotic, antinflammatory properties of PTX. ► PTX as adjuvant with PZQ lower cytokine release, free radicals, collagen deposition. ► Clinical studies are important to reach a solid conclusion about the reality of PTX.