Lack of signaling by IL-4 or by IL-4/IL-13 has more attenuating effects on Leishmania amazonensis dorsal skin - than on footpad-infected mice

► C57BL/6 mice injected in the rump with Leishmania amazonensis develop severe lesions. ► IL-4 is not the only susceptibility factor to L. amazonensis infection. ► IL4Rα−/− BALB/c mice develop minimal lesions in response to L. amazonensis infection. ► Lamazonensis parasites persist in the absence of lesion in IL-4−/− C57BL/6 mice.