Kinetics of Foxp3-expressing regulatory cells in experimental Toxocara canis infection

► Foxp3-expressing regulatory cell counts increase over time in Toxocara-induced hepatic inflammation. ► Splenic expression of Foxp3 transcripts increases over time in Toxocara-infected mice. ► Mice sensitized by excretory-secretory antigen of Toxocara before experimental infection exhibit earlier appearance of Foxp3+ regulatory cells. ► Foxp3-expressing regulatory cells seem to play a role in Toxocara-induced immunopathology.