Trypanosoma evansi: Concentration of 3-nitrotyrosine in the brain of infected rats

► Trypanosoma evansi is a flagellate protozoan can cause neurological disorders in horses and cattle. ► The biological roles of nitric oxide (NO) in physiologic processes are many, such as neurotransmission and immune system. ► Excessive production of NO can cause neurotoxicity, as well as neurological signs observed in Trypanosomosis. ► The indirect determination of NO can be made by the detection of residues of 3-nitrotyrosine (3-NT). ► Infection with T. evansi causes changes in the concentrations of protein 3-NT in the CNS of rats. ► The increase of 3-NT may be related to inflammation and control of parasitemia at low levels.