کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6312151 | 1618961 | 2014 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A multi-biomarker assessment of single and combined effects of norfloxacin and sulfamethoxazole on male goldfish (Carassius auratus)
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
شیمی زیست محیطی
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چکیده انگلیسی
In the present study, the sublethal effects of norfloxacin alone and in combination with sulfamethoxazole in goldfish (Carassius auratus) were investigated, the biomarkers including acetylcholinesterase (AChE) in brain, 7-ethoxyresorufin O-deethylase (EROD), glutathione S-transferase (GST), and superoxides dismutase (SOD) activities in liver, vitellogenin (Vtg) in serum and DNA damage in gonad were determined after 1, 2, 4 and 7 days of exposure. Brain AChE activity was significantly inhibited by norfloxacin (â¥0.4 mg/L) after 4 and 7 days and the mixtures with sulfamethoxazole (â¥0.24 mg/L) after 4 days of exposure, and significant concentration-response relationships were obtained. Liver EROD, GST and SOD activities were significantly increased by the individual and mixed pharmaceuticals in most cases and exhibited analogously bell-shaped concentration-response curves. Serum Vtg was increased by the highest concentration of norfloxacin and two higher concentrations of the mixtures. Higher concentrations of the test antibiotics induced significant DNA damage in a concentration- and time-dependent manner. The results indicated that selected antibiotics possesses cytotoxic and genotoxic potential against the non-target organism C. auratus.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Ecotoxicology and Environmental Safety - Volume 102, April 2014, Pages 12-17
Journal: Ecotoxicology and Environmental Safety - Volume 102, April 2014, Pages 12-17
نویسندگان
Jianchao Liu, Guanghua Lu, Donghai Wu, Zhenhua Yan,