کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6316978 | 1619173 | 2015 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Ecotoxicogenomic assessment of diclofenac toxicity in soil
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کلمات کلیدی
NSAIDSnAChRDissipation - انصرافNon-steroidal anti-inflammatory drugs - داروهای ضد التهابی غیر استروئیدیDiclofenac - دیکلوفناکSoil ecotoxicology - زیست شناسی زیستی خاکFolsomia candida - فالزومیا کاندیداTranscriptomics - متن ترانهGene ontology - هستیشناسی ژنیnicotinic acetylcholine receptor - گیرنده استیلکولین نیکوتین
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
شیمی زیست محیطی
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
Diclofenac is widely used as nonsteroidal anti-inflammatory drug leaving residues in the environment. To investigate effects on terrestrial ecosystems, we measured dissipation rate in soil and investigated ecotoxicological and transcriptome-wide responses in Folsomia candida. Exposure for 4 weeks to diclofenac reduced both survival and reproduction of F. candida in a dose-dependent manner. At concentrations â¥200 mg/kg soil diclofenac remained stable in the soil during a 21-day incubation period. Microarrays examined transcriptional changes at low and high diclofenac exposure concentrations. The results indicated that development and growth were severely hampered and immunity-related genes, mainly directed against bacteria and fungi, were significantly up-regulated. Furthermore, neural metabolic processes were significantly affected only at the high concentration. We conclude that diclofenac is toxic to non-target soil invertebrates, although its mode of action is different from the mammalian toxicity. The genetic markers proposed in this study may be promising early markers for diclofenac ecotoxicity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Environmental Pollution - Volume 199, April 2015, Pages 253-260
Journal: Environmental Pollution - Volume 199, April 2015, Pages 253-260
نویسندگان
Guangquan Chen, Michiel W. den Braver, Cornelis A.M. van Gestel, Nico M. van Straalen, Dick Roelofs,