کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6317962 1619176 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Proteomic profile in Perna viridis after exposed to Prorocentrum lima, a dinoflagellate producing DSP toxins
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست شیمی زیست محیطی
پیش نمایش صفحه اول مقاله
Proteomic profile in Perna viridis after exposed to Prorocentrum lima, a dinoflagellate producing DSP toxins
چکیده انگلیسی


- Response of mussel to toxicity of OA was explored using proteomic approach.
- The presence of Prorocentrum lima strongly enhanced OA accumulation in mussel gill.
- P. lima may induce cytoskeleton disorganization and oxidative stress in mussel.
- Our findings provide global information for early response to OA chronic exposure.

In the current study, we compared protein profiles in gills of Perna viridis after exposure to Prorocentrum lima, a dinoflagellate producing DSP toxins, and identified the differential abundances of protein spots using 2D-electrophoresis. After exposure to P. lima, the level of okadaic acid (a main component of DSP toxins) in gills of P. viridis significantly increased at 6 h, but mussels were all apparently healthy without death. Among the 28 identified protein spots by MALDI TOF/TOF-MS, 12 proteins were up-regulated and 16 were down-regulated in the P. lima-exposed mussels. These identified proteins were involved in various biological activities, such as metabolism, cytoskeleton, signal transduction, response to oxidative stress and detoxification. Taken together, our results indicated that the presence of P. lima caused DSP toxins accumulation in mussel gill, and might consequently induce cytoskeletonal disorganization, oxidative stress, a dysfunction in metabolism and ubiquitination/proteasome activity.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Environmental Pollution - Volume 196, January 2015, Pages 350-357
نویسندگان
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