Computational toxicology: Physiologically based pharmacokinetic models (PBPK) for lifetime exposure and bioaccumulation of polybrominated diphenyl ethers (PBDEs) in marine mammals

► PBPK modeling is a non-invasive and non-destructive tool for risk assessment. ► PBPK modeling was used to study the kinetics of several PBDEs in harbour porpoises. ► Harbour porpoises are sensitive to pollution and therefore ideal model organisms. ► Black Sea data were used for model parameterization. ► North Sea data were used for assessing temporal trends (1990-2008).