کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6342 | 484 | 2013 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
EGRF conjugated PEGylated nanographene oxide for targeted chemotherapy and photothermal therapy
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
بیو مهندسی (مهندسی زیستی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: EGRF conjugated PEGylated nanographene oxide for targeted chemotherapy and photothermal therapy EGRF conjugated PEGylated nanographene oxide for targeted chemotherapy and photothermal therapy](/preview/png/6342.png)
چکیده انگلیسی
Low accumulation of chemotherapeutic agent in tumor tissue and multidrug resistance (MDR) present a major obstacle to curing cancer treatment. Therefore, how to combine several therapeutics in one system is a key issue to overcome the problem. Here, we demonstrate epidermal growth factor receptor (EGFR) antibody-conjugated PEGylated nanographene oxide (PEG-NGO) to carry epirubicin (EPI) for tumor targeting and triple-therapeutics (growth signal blocking, chemotherapy, photothermal therapy) in tumor treatment. This synergistic targeted treatment simultaneously enhances the local drug concentration (6.3-fold) and performs the ultra-efficient tumor suppression to significantly prolong the mice survival (over the course of 50 days).
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomaterials - Volume 34, Issue 29, September 2013, Pages 7204–7214
Journal: Biomaterials - Volume 34, Issue 29, September 2013, Pages 7204–7214
نویسندگان
Hung-Wei Yang, Yu-Jen Lu, Kun-Ju Lin, Sheng-Chieh Hsu, Chiung-Yin Huang, Shu-Han She, Hao-Li Liu, Chih-Wen Lin, Min-Cong Xiao, Shiaw-Pyng Wey, Pin-Yuan Chen, Tzu-Chen Yen, Kuo-Chen Wei, Chen-Chi M. Ma,