کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6342 484 2013 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
EGRF conjugated PEGylated nanographene oxide for targeted chemotherapy and photothermal therapy
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی بیو مهندسی (مهندسی زیستی)
پیش نمایش صفحه اول مقاله
EGRF conjugated PEGylated nanographene oxide for targeted chemotherapy and photothermal therapy
چکیده انگلیسی

Low accumulation of chemotherapeutic agent in tumor tissue and multidrug resistance (MDR) present a major obstacle to curing cancer treatment. Therefore, how to combine several therapeutics in one system is a key issue to overcome the problem. Here, we demonstrate epidermal growth factor receptor (EGFR) antibody-conjugated PEGylated nanographene oxide (PEG-NGO) to carry epirubicin (EPI) for tumor targeting and triple-therapeutics (growth signal blocking, chemotherapy, photothermal therapy) in tumor treatment. This synergistic targeted treatment simultaneously enhances the local drug concentration (6.3-fold) and performs the ultra-efficient tumor suppression to significantly prolong the mice survival (over the course of 50 days).

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomaterials - Volume 34, Issue 29, September 2013, Pages 7204–7214
نویسندگان
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