Thermal and pH dual responsive alginate/CaCO3 hybrid membrane prepared under compressed CO2

► Biomimetic alginate/CaCO3 membranes were prepared under compressed CO2. ► Aliphatic PUA was employed as the thermal-responsive composition. ► The interaction between PAA and PUA contributed the formation of CaCO3. ► The release profile was sustained with the introducing of CaCO3. ► Drug release behaviors were pH- and thermal- responsive.