Relationship between serum ferritin level and blood mercury concentration using data from the Korean national health and nutrition examination survey (2010-2012)

Background: Studies on the association between serum ferritin levels (S-Ft) and blood mercury concentrations (B-Hg) are scarce. The objective of this study was to investigate the relationships between these two parameters using a large-scale nationwide representative sample of the Korean males.Method: A nationwide cross-sectional study was conducted to examine the relationship between S-Ft and B-Hg in 2832 men over 19 years of age (aged 20-87 years), using data from the 2010-2012 Korean National Health and Nutrition Examination Survey. The odds ratios (ORs) and 95% confidence intervals (CIs) for high B-Hg (>75th percentile) were calculated across S-Ft quartiles using multiple logistic regression analyses.Results: Mean values of B-Hg gradually increased in accordance with the quartiles of S-Ft (P-trend<0.001). The odds ratio (95% CI) for high B-Hg with the doubling of S-Ft was 1.51 (1.25-1.84) after adjusting for age, fish/shellfish consumption, rice consumption, waist circumference, cigarette smoking, alcohol intake, regular exercise, blood pressure, fasting plasma glucose, triglyceride, and high-density lipoprotein cholesterol. Compared with the lowest quartiles of B-Hg, the ORs (95% CI) for high S-Ft in the 3rd and 4th quartiles were 2.09 (1.17-3.73) and 2.73 (1.55-4.79) after adjusting for the same co-variables.Conclusion: We found a positive relationship between S-Ft and B-Hg in a representative population sample of Korean adult men. Our results suggested S-Ft as a tool for environmental Hg exposure assessment.