کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6369220 1623811 2016 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Simulating evolution of protein complexes through gene duplication and co-option
ترجمه فارسی عنوان
شبیه سازی تکامل پروتئین ها از طریق تکثیر ژن ها و گزینه های مشترک
کلمات کلیدی
سیر تکاملی، پیچیدگی، همکاری، مدل کامپیوتری، ارگان دیجیتال،
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم کشاورزی و بیولوژیک (عمومی)
چکیده انگلیسی


- Digital organisms model evolution of protein complexes with novel functions.
- Greater complexity and interlocking complexity evolve over time.
- Gene duplication, mutation, and co-option are principle mechanisms.
- Many model parameters (e.g. mutation rates, selection, binding) can be varied.

We present a model of the evolution of protein complexes with novel functions through gene duplication, mutation, and co-option. Under a wide variety of input parameters, digital organisms evolve complexes of 2-5 bound proteins which have novel functions but whose component proteins are not independently functional. Evolution of complexes with novel functions happens more quickly as gene duplication rates increase, point mutation rates increase, protein complex functional probability increases, protein complex functional strength increases, and protein family size decreases. Evolution of complexity is inhibited when the metabolic costs of making proteins exceeds the fitness gain of having functional proteins, or when point mutation rates get so large the functional proteins undergo deleterious mutations faster than new functional complexes can evolve.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Theoretical Biology - Volume 399, 21 June 2016, Pages 22-32
نویسندگان
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