کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6369387 1623821 2016 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A stochastic mechanism for signal propagation in the brain: Force of rapid random fluctuations in membrane potentials of individual neurons
ترجمه فارسی عنوان
یک مکانیزم تصادفی برای انتشار سیگنال در مغز: نیروی نوسانات تصادفی سریع در پتانسیل غشاء نورون های فردی
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم کشاورزی و بیولوژیک (عمومی)
چکیده انگلیسی
There are two functionally important factors in signal propagation in a brain structural network: the very first synaptic delay-a time delay about 1 ms-from the moment when signals originate to the moment when observation on the signal propagation can begin; and rapid random fluctuations in membrane potentials of every individual neuron in the network at a timescale of microseconds. We provide a stochastic analysis of signal propagation in a general setting. The analysis shows that the two factors together result in a stochastic mechanism for the signal propagation as described below. A brain structural network is not a rigid circuit rather a very flexible framework that guides signals to propagate but does not guarantee success of the signal propagation. In such a framework, with the very first synaptic delay, rapid random fluctuations in every individual neuron in the network cause an “alter-and-concentrate effect” that almost surely forces signals to successfully propagate. By the stochastic mechanism we provide analytic evidence for the existence of a force behind signal propagation in a brain structural network caused by rapid random fluctuations in every individual neuron in the network at a timescale of microseconds with a time delay of 1 ms.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Theoretical Biology - Volume 389, 21 January 2016, Pages 225-236
نویسندگان
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