کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6369736 1623832 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
PCD-GED: Protein complex detection considering PPI dynamics based on time series gene expression data
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم کشاورزی و بیولوژیک (عمومی)
پیش نمایش صفحه اول مقاله
PCD-GED: Protein complex detection considering PPI dynamics based on time series gene expression data
چکیده انگلیسی
Detection of protein complexes from protein-protein interaction (PPI) networks is essential to understand the function of cell machinery. However, available PPIs are static, and cannot reflect the dynamics inherent in real networks. Our method uses time series gene expression data in addition to PPI networks to detect protein complexes. The proposed method generates a series of time-sequenced subnetworks (TSN) according to the time that the interactions are activated. It finds, from each TSN, the protein complexes by employing the weighted clustering coefficient and maximal weighted density concepts. The final set of detected protein complexes are obtained from union of all complexes from different subnetworks. Our findings suggest that by employing these considerations can produce far better results in protein complex detection problem.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Theoretical Biology - Volume 378, 7 August 2015, Pages 31-38
نویسندگان
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