کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6369819 | 1623838 | 2015 | 11 صفحه PDF | دانلود رایگان |
- Acetylcholinesterase have surfaced as therapeutic targets for the treatment of cognitive impairments associated with Alzheimer's.
- In this study we have analyzed the protein-protein interactions between acetylcholinesterase receptor and venom toxins.
- Binding site residue information was collected and in detail analysis of their binding interactions with venom ligands was done using computational approaches and tools.
Acetylcholinesterases (AChE) are enzymes that function in hydrolyzing the neurotransmitter acetylcholine. Diminished levels of acetylcholine have been reported for various neurodegenerative diseases, especially Alzheimer's. Therefore, acetylcholinesterase inhibitors are being considered quite effective in treating these diseases. Fasciculin 2 is a toxin isolated from Eastern green mamba that had been reported as a reversible acetylcholinesterase inhibitor. In this study, we have reported the in silico analysis of venom toxins via various computational tools used for drug designing, to find out the protein-protein interaction of these toxins in complex with acetylcholinesterase enzyme. In total 15 toxins have been selected from the venoms of various species as ligand dataset, to study their binding interactions with the acetylcholinesterase enzyme.
Journal: Journal of Theoretical Biology - Volume 372, 7 May 2015, Pages 107-117