On the relation between reactions and complexes of (bio)chemical reaction networks

► Connection between two methodologies, flux coupling analysis and chemical reaction network theory, is established. ► Flux-focused approaches and concentration-centric approaches are bridged. ► Two mappings are introduced, of which one is a homomorphism, and which provide an interface between the two approaches. ► The mathematical formulation relies on the simple concepts of equivalence classes, partitions and lattices. ► The approach can reveal a significant reduction of complexity of the considered chemical reaction network.