A hypothesis on the formation of the primary ossification centers in the membranous neurocranium: A mathematical and computational model

► We have developed a theoretical model for the skull ossification centers. ► The model predicts the formation of primary ossification centers in the Calvaria. ► This paper describes a reaction-diffusion model of two molecules (BMP and Noggin). ► We assumed that the BMP and the maturity of mesenchymal cells lead to the ossification.