کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6371752 | 1319022 | 2006 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Stage-dependent density effect in the cell cycle of budding yeast
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
علوم کشاورزی و بیولوژیک (عمومی)
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چکیده انگلیسی
Yeasts in culture media grow exponentially in early period but eventually stop growing. The saturation of population growth is due to “density effect”. The budding yeast, Saccharomyces cerevisiae, is known to exhibit a stage-dependent cell division. Daughter cell, which gives no birth, has longer generation time than mother, because daughter needs maturity time. So far, investigations have been restricted in exponential or non-crowding state; very little is known for the stage dependence of density effect. Here we present a lattice gas model to explore the population dynamics of crowding period. We compare theoretical results with experimental data, and find a stage-dependent density effect. Although small daughter cells can develop to a critical size, the reproduction of large daughter cells suddenly stops when the total density exceeds some critical level. Our results imply the existence of an inhibitor that specifically halts the reproduction of matured daughter cell.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Theoretical Biology - Volume 242, Issue 3, 7 October 2006, Pages 736-742
Journal: Journal of Theoretical Biology - Volume 242, Issue 3, 7 October 2006, Pages 736-742
نویسندگان
Kei-ichi Tainaka, Jin Yoshimura, Takashi Ushimaru,