Optimization of Copaiba oil-based nanoemulsions obtained by different preparation methods

- Copaiba oil nanoemulsions were prepared by two methods.
- 2IV4-1 fractional factorial design was used to optimize the formulation.
- Formulations with high oil content were obtained.
- Stability at 4 and 25 °C was monitored for 90 days.
- MCT aided fixing the copaiba oil volatile fraction in nanoemulsions.