کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
638418 | 1456171 | 2007 | 9 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Thermally on–off switching membranes of poly(N-isopropylacrylamide) immobilized in track-etched polycarbonate films Thermally on–off switching membranes of poly(N-isopropylacrylamide) immobilized in track-etched polycarbonate films](/preview/png/638418.png)
The objective of this research was to prepare temperature-sensitive composite membranes for controlled drug release. Cross-linked N-isopropylacrylamide (NIPAAm) polymer network were immobilized into microporous track-etched polycarbonate (PC) films. The effective pore sizes were regulated by the swelling or shrinkage of the PNIPAAm at temperatures at the vicinity of its lower-critical solution temperature (LCST). The resulting membranes were characterized in terms of grafting yield, membrane thickness, Fourier transform infrared (FTIR) spectra and scanning electron micrograph (SEM). The NIPAAm-PC composite demonstrated fast and reversible swelling changes in the 30–40 °C temperature range. The on–off water permeability ratio was significantly higher compared with the literature data. The drug permeabilities of 4-acetamidophenol and ranitidine HCl in the resulting membranes were determined at temperatures between 30 and 40 °C. These membranes exhibited on–off ratios of up to 11 and 20 for the model drugs, respectively. These ratios were stable after 1 month of storage.
Journal: Journal of Membrane Science - Volume 301, Issues 1–2, 1 September 2007, Pages 142–150