کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6396560 1628481 2014 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Pharmacokinetics of caffeine and its metabolites in plasma and urine after consuming a soluble green/roasted coffee blend by healthy subjects
ترجمه فارسی عنوان
فارماکوکینتیک کافئین و متابولیت های آن در پلاسما و ادرار پس از مصرف یک مخلوط قهوه سبز / فلفل محلول در افراد سالم
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش تغذیه
چکیده انگلیسی
Coffee is widely consumed worldwide; therefore, the methylxanthines contained in coffee, mainly caffeine (CF), are among the most abundant bioactive compounds in our diet. In the present work, the bioavailability and metabolism of methylxanthines in a commercial soluble green/roasted coffee blend was studied. After a 3-day restriction of methylxanthine-containing foods, fasting healthy subjects (12 men and women) consumed the coffee product containing 70.69 mg CF and 0.119 mg theobromine (TB). Plasma samples were taken before (t = 0 h) and after coffee consumption at different time points (0.5, 1, 1.5, 2, 3, 4, 5, 6, 8, 9, 10 and 12 h). Urine was collected at baseline (− 2-0 h) and at different intervals (0-2, 2-5, 5-8, 8-12 and 12-24 h). Samples were analyzed by HPLC-DAD and LC-MS-QToF, and pharmacokinetic parameters were calculated. CF was the main methylxanthine found in plasma (Cmax = 10.50 μM, Tmax = 1.2 h). In addition, seven methylxanthines and methyluric acids were detected between 0.5 and 12 h after coffee intake, paraxanthine (PX) being the major metabolite (Cmax = 3.36 μM), followed by 1-methyluric acid (1-MU; Cmax = 1.44 μM) and 1-methylxanthine (1-MX; Cmax = 1.27 μM), identified in plasma samples for the first time. In 24 h urine, eleven methylxanthines and methyluric acids were detected, 1-MU being the major metabolite (Cmax = 150.52 μM, Tmax = 12 h) amounting to 67.7% of the total urinary metabolites. In conclusion, a rapid absorption, metabolization and excretion of caffeine and its derived methylxanthines and methyluric acids have been observed after consumption of a green/roasted coffee product.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food Research International - Volume 64, October 2014, Pages 125-133
نویسندگان
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