Effects of Goishi tea on diet-induced obesity in mice

Goishi tea is a post-fermented tea produced in Kochi, Japan. This study aimed to investigate the anti-obesity effect of Goishi tea by using 3T3L-1 cells and mice model. In 3T3L-1 cells, Goishi tea showed a significant stimulatory effect on fat decomposition compared with green tea. The C57BL/6J mice were fed with a high-fat diet to create a diet-induced obesity model for investigating the benefits of Goishi tea. Mice were categorized into 5 groups. Within the high-fat diet groups, body mass, blood glucose and visceral fat mass were found to be lower among the Goishi tea group compared with the tap water groups. Having conducted histological evaluation of adipocytes, an increase in fat was observed in the high-fat diet groups compared with the normal diet groups. The degree of fat increase was smaller among the Goishi tea and green tea groups compared with the tap water groups. Results suggested that Goishi tea had a suppressive effect on fat cell enlargement during the progression of obesity as well as a suppressive effect on factors such as tumor necrosis factor alpha and interleukin-6. In conclusion, Goishi tea is likely effective against diet-induced obesity.