کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6402772 1330890 2014 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Antiproliferative, antimutagenic and antioxidant activities of a Brazilian tropical fruit juice
ترجمه فارسی عنوان
فعالیت های ضد انعقادی، ضد انعطاف پذیر و آنتی اکسیدانی یک میوه آبمیوه ای برزیل
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش تغذیه
چکیده انگلیسی


- Tropical fruit juice showed high total phenolic and flavonoid contents.
- High antioxidant value was found by ABTS, ORAC, PSC and CAA assays.
- Phenolic compounds and organic acid may be contributed to its antioxidant activity.
- Proliferation of HepG2 cells was inhibited after exposure to the fruit juice.
- All concentration evaluated showing antimutagenic activity in mice.

This paper reports the antioxidant activity of a tropical fruit juice and its antiproliferative and antimutagenic effects. The antioxidant activity was determined by several different methods, such as ORAC, ABTS, PSC (peroxyl radical scavenging capacity) and CAA (cellular antioxidant activity). The total of phenolics and flavonoids were determined, and the phenolic compounds were identified by LC-DAD-ESI-MS. The juice showed high total phenolic and flavonoid contents (838.44 ± 30.27 g GAE/100 g and 219.45 ± 12.27 mg CE/100 g DW, respectively). According to the PSC, CAA, ABTS and ORAC assays, the tropical fruit juice showed a high antioxidant value of 308.39 ± 3.10 μM AEE/100 g, 26.76 ± 4.47 μM QE/100 g, 167.17 ± 4.10 μM TE/g DW and 235.90 ± 11.90 μM TE/g DW, respectively. The proliferation of HepG2 was significantly inhibited, in a dose-dependent manner, by exposure to the tropical fruit juice. Antimutagenic activity was investigated by micronucleous test in mice, and all doses evaluated (30, 100 and 300 mg/kg b.w.) showed beneficial effects. As a consequence, these results encourage further studies on the pharmacological and functional properties of this tropical fruit juice, in order to evaluate its use as a functional food, due to its beneficial health properties.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: LWT - Food Science and Technology - Volume 59, Issue 2, Part 2, December 2014, Pages 1319-1324
نویسندگان
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