کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6462436 1421978 2017 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Demographic, clinical and pathological features of sudden deaths due to myocarditis: Results from a state-wide population-based autopsy study
ترجمه فارسی عنوان
مشخصات دموگرافیک، بالینی و آسیب شناختی مرگ ناگهانی ناشی از میوکاردیت: نتایج یک مطالعه کلیشه ای مبتنی بر جمعیت در سراسر کشور
کلمات کلیدی
مرگ ناگهانی، میوکاردیت، کاردیومیوپاتی کامل قطعیت تشخیص،
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی


- Sudden deaths from myocarditis are studied over a 10-year period.
- Demographic, clinical and pathological features are analyzed.
- The incidence of fatal myocarditis is 0.70% of autopsied sudden deaths.
- In 17.5% cases, no significant myocyte necrosis is identified.
- Determination of myocarditis as cause of death remains a challenge to pathologist.

Causes of sudden cardiac deaths have been widely reported with limited data focused specifically on myocarditis. A retrospective review of cases from the Office of the Chief Medical Examiner (OCME), State of Maryland yielded a total of 103 sudden unexpected deaths (SUDs) due to myocarditis (0.17% of all SUDs and 0.70% of autopsied SUDs) from 2005 through 2014. Most deaths occurred in patients <30 years of age with a male:female ratio 1.3:1. Of the 103 cases, 45 (43.7%) patients were witnessed collapsed. Four deaths occurred during exertion, such as exercising at the gym or performing heavy physical work, and 2 deaths were associated with emotional stress. The common cardiac macroscopic findings included ventricular dilatation (39.8%), mild coronary stenosis (17.5%), mottled myocardial appearance (15.5%), and myocardial fibrosis (10.7%). The histological classification of myocarditis was based on the predominant type of inflammatory cell infiltration. In our study group, lymphocytic myocarditis was most common, accounting for 56 cases (54.4%), followed by neutrophilic (32 cases, 31.7%), eosinophilic (13 cases, 12.6%) and giant cell type (2 cases, 1.9%). Microscopic examination revealed myocyte necrosis in 69 cases (67.0%) and interstitial or perivascular fibrosis in 48 cases (46.6%). The percentage of myocyte necrosis was 75.0% (42/58 cases) in lymphocytic, 65.6% (21/31 cases) in neutrophilic, 30.8% (4/13 cases) in eosinophilic, and 100% (2/2 cases) in giant cell myocarditis. Determination of myocarditis as cause of death continues to present a major challenge to forensic pathologists, because histopathologic findings can be subtle and the diagnosis of myocarditis remains difficult.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Forensic Science International - Volume 272, March 2017, Pages 81-86
نویسندگان
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