A multifunctional DNA origami as carrier of metal complexes to achieve enhanced tumoral delivery and nullified systemic toxicity

Herein we present a multifunctional DNA origami as biocompatible nanocarrier of ruthenium complexes (RuPOP) for advanced cancer therapeutics. The tetrahedral Bio-cage with cancer-targeted ability increases the loading efficacy of RuPOP and drastically promotes its tumoral accumulation. Bio-cage@Ru undergoing safe circulation in blood efficiently targets nucleus and strengthens enhanced antitumoral effects without causing systemic toxicities.268