کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6485157 387 2016 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The effect of surface modification of mesoporous silica micro-rod scaffold on immune cell activation and infiltration
ترجمه فارسی عنوان
اثر اصلاح سطحی داربست میکرو پد سیلیکا مزوپور بر فعال سازی و نفوذ سلول های ایمنی
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی بیو مهندسی (مهندسی زیستی)
چکیده انگلیسی
Biomaterial scaffold based vaccines show significant potential in generating potent antigen-specific immunity. However, the role of the scaffold surface chemistry in initiating and modulating the immune response is not well understood. In this study, a mesoporous silica micro-rod (MSR) scaffold was modified with PEG, PEG-RGD and PEG-RDG groups. PEG modification significantly enhanced BMDC activation marker up-regulation and IL-1β production in vitro, and innate immune cell infiltration in vivo. PEG-RGD MSRs and PEG-RDG MSRs displayed decreased inflammation compared to PEG MSRs, and the effect was not RGD specific. Finally, the Nlrp3 inflammasome was found to be necessary for MSR stimulated IL-1β production in vitro and played a key role in regulating immune cell infiltration in vivo. These findings suggest that simply modulating the surface chemistry of a scaffold can regulate its immune cell infiltration profile and have implications for the design and development of new material based vaccines.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomaterials - Volume 83, March 2016, Pages 249-256
نویسندگان
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