کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6485527 | 402 | 2015 | 28 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Low-aspect ratio nanopatterns on bioinert alumina influence the response and morphology of osteoblast-like cells
ترجمه فارسی عنوان
نانوپارایتی های نسبتا کم نسبت به آلومینای بیوانرتری تاثیر واکنش و مورفولوژی سلول های شبه استئوپلاستی دارند
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کلمات کلیدی
آلومینا، نانوپوتوگرافی، پرتو یون استئوبلاست،
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
بیو مهندسی (مهندسی زیستی)
چکیده انگلیسی
Topographical features on the nanometer scale are known to influence cellular behavior. The response of specific cell types to various types of surface structures is currently still being investigated. Alumina ceramics play an important role as biomaterials, e.g., in medical and dental applications. In this study, we investigated the influence of nanoscale surface features with low aspect ratio (< 0.1) on the response of osteoblast-like MG-63 cells. To this end, low-energy ion irradiation was employed to produce shallow nanoscale ripple patterns on Al2O3(0001) surfaces with lateral periodicities of 24Â nm and 179Â nm and heights of only 0.7 and 11.5Â nm, respectively. The nanopatterning was found to increase the proliferation of MG-63 cells and may lead to pseudopodia alignment along the ripples. Furthermore, focal adhesion behavior and cell morphology were analyzed. We found that MG-63 cells are able to recognize surface nanopatterns with extremely low vertical variations of less than 1Â nm. In conclusion, it is shown that surface topography in the sub-nm range significantly influences the response of osteoblast-like cells.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomaterials - Volume 62, September 2015, Pages 58-65
Journal: Biomaterials - Volume 62, September 2015, Pages 58-65
نویسندگان
Isabel Wittenbrink, Anne Hausmann, Karolina Schickle, Ines Lauria, Roswitha Davtalab, Morten Foss, Adrian Keller, Horst Fischer,