کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6486371 432 2015 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Low-bandgap biophotonic nanoblend: A platform for systemic disease targeting and functional imaging
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی بیو مهندسی (مهندسی زیستی)
پیش نمایش صفحه اول مقاله
Low-bandgap biophotonic nanoblend: A platform for systemic disease targeting and functional imaging
چکیده انگلیسی
Photonic nanomaterials have found wide applications in theranostics. We introduce here a design of all-organic photonic nanoparticles, different from traditional ones, in which we utilize nanoblend of a low-bandgap π-conjugated polymer (LB-CP) and polystyrene as the photonic core, surrounded by an FDA-approved polymeric surfactant. This design provides capability for efficient deep tissue imaging using highly penetrating near-infrared (NIR) excitation and emission of LB-CP and also allows us to incorporate a NIR phosphorescent oxygen-sensitive dye in the core to serve as a dual-emissive probe for hypoxia imaging. These biophotonic nanoblend (BNB) particles (∼20 nm in diameter) show facile blood circulation, efficient disease targeting and minimal liver filtration as well as sustained renal excretion in the intravenously administered mouse models, as noninvasively visualized by the NIR emission signals. In diseased mouse models, pathological tissue deoxygenation at hypoxic sites was successfully detected with ratiometric spectral information. We also show that our nanoformulation exhibits no apparent toxicity, thus serving as a versatile biophotonics platform for diagnostic imaging.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomaterials - Volume 39, January 2015, Pages 225-233
نویسندگان
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