کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
654584 | 885252 | 2009 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effect of protein degradation in the axon on the speed of the bell-shaped concentration wave in slow axonal transport
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
جریان سیال و فرایندهای انتقال
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
This paper investigates the effect of degradation of proteins transported by means of slow axonal transport (due to enzyme-mediated breakdown of proteins) on the speed of the bell-shaped wave of protein concentration propagating toward the synapse of the axon. Another issue investigated in this paper is the effect of protein degradation on the traffic jam caused by a decay of microtubule tracks at a certain location in the axon. The decay of microtubule tracks may be caused by misregulation of microtubule-associated proteins resulting from an imbalance in intracellular signaling or by mutations of these proteins. Axonal swellings caused by such traffic jams hinder axonal transport; they are a likely cause of various neurodegenerative diseases, including Alzheimer's and Parkinson's diseases and the Down syndrome.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Communications in Heat and Mass Transfer - Volume 36, Issue 7, August 2009, Pages 641-645
Journal: International Communications in Heat and Mass Transfer - Volume 36, Issue 7, August 2009, Pages 641-645
نویسندگان
A.V. Kuznetsov, A.A. Avramenko, D.G. Blinov,