کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6552592 | 160445 | 2014 | 29 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The analytical investigation of synthetic street drugs containing cathinone analogs
ترجمه فارسی عنوان
تحقیقات تحلیلی از داروهای خیابانی مصنوعی حاوی مقادیر کاتیونون
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی
Synthetic drugs, often marketed as “legal highs,” are entering the drug market at an accelerated pace. Analysis of these “designer drugs” and the determination of their composition are necessary in order to aid law enforcement and also to understand what potential users may be subjected to. Ten synthetic cathinones were identified in 14 separate street samples analyzed utilizing a variety of techniques, including gas chromatography with mass spectrometric detection (GC-MS) and flame ionization (GC-FID). Additionally, preparatory high performance liquid chromatography (HPLC) for the fractionation of multi-component samples and the use of direct infusion tandem mass spectrometry (MS/MS) was necessary to identify compounds which were not available as reference materials. These cathinones include 3,4-methylenedioxy pyrovalerone (MDPV), 3,4-methylenedioxy-α-pyrrolidinobutiophenone (MDPBP), 4-fluoromethcathinone (4-FMC), butylone, mephedrone, naphyrone, 4-methylethcathinone (4-MEC), ethcathinone, α-pyrrolidinopentiophenone (α-PVP), and 3-methyl-α-pyrrolidinopropiophenone (3-MPPP). Concentrations of the active compounds varied between samples. For example, MDPV was determined to be the most common cathinone. It was found in five of the 14 samples and ranged from 11% to 73% between samples.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Forensic Science International - Volume 234, January 2014, Pages 50-56
Journal: Forensic Science International - Volume 234, January 2014, Pages 50-56
نویسندگان
Amanda M. Leffler, Philip B. Smith, Adriana de Armas, Frank L. Dorman,