Rheological and dynamical characterization of blood analogue flows in a slit

• We study blood analogue potential of H2O/glycerine/xanthan mixtures through viscosity.
• Water/glycerine (35% w/w)/xanthan (0.02% w/w) solution mimics well blood viscosity.
• We characterize dynamics of blood analogue flows in open slits with μPIV and CFD.
• Results refer to flow rates 4.3 ⩽ Q ⩽ 25.3 L/h.
• Wall shear stresses are bellow haemolysis threshold but may trigger thrombus formation.

Thrombus formation and haemolysis are blood destructive phenomena depending on the flow hydrodynamics, particularly the shear stresses. This work addresses this issue by characterizing experimentally (using the micro-PIV technique) and numerically (using CFD) steady-state Newtonian (water and water/glycerine solutions) fluid flows and non-Newtonian (water/glycerine/xanthan) blood analogue flows, in a slit with a height of 1.3 mm and a width of 30 mm. The results obtained may provide useful information in the design of extracorporeal devices manipulating blood for diagnosis and therapeutics. Results from CFD showed that the Herschel–Bulkley viscosity model yields velocity predictions in excellent agreement with the experimental data obtained with the micro-PIV. Viscosity measurements evidenced that the water/glycerine (35% w/w)/xanthan (0.02% w/w) solution mimics well the blood global viscosity, exhibiting velocity profile shapes in fully developed flows flattened at the centre, typical of shear-thinning fluids. The maximum shear stresses obtained experimentally (1.39–3.11 Pa) for the blood analogue flows at the studied rates (6.7–25.3 L/h) evidence that haemolysis is unlikely to occur since lysis threshold values are 150 Pa for erythrocytes, 10 Pa for leucocytes and 7.5 Pa for platelets. However, the smallest flow rate cases may be of concern in blood circulation by yielding clot formation near the walls since the shear stresses there are bellow the thrombus/coagulation threshold (1.0–1.8 Pa).

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