Intensified crystallization in complex media: Heuristics for crystallization of platform chemicals

► Heuristics for selection of crystallization based ISPR techniques were developed. ► These heuristics have been applied to the top-twelve platform chemicals. ► ISPR by crystallization is possible for all of the top-twelve platform chemicals. ► Process configuration is important: in-situ preferred over in-stream. ► In-situ co-crystallization is most favorable due to its tunable solid state.