A comparative study on batch and fed-batch cultures of oleaginous yeast Cryptococcus sp. in glucose-based media and corncob hydrolysate for microbial oil production

► Effect of culture mode on the production of oleaginous yeast lipid was studied. ► Accumulation of lipid strongly depended on the initial concentrations of glucose. ► Fed-batch culture diminished the substrate's inhibition of lipid-accumulation. ► Maximal lipid content in the Cryptococcus sp. were 61.3% on dried weight basis.