کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6663 510 2012 19 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Biomedical applications of amino acid-modified chitosans: A review
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی بیو مهندسی (مهندسی زیستی)
پیش نمایش صفحه اول مقاله
Biomedical applications of amino acid-modified chitosans: A review
چکیده انگلیسی

The presence of reactive primary amines in the backbone structure of chitosan, enables the derivatisation with different functional groups and thereby improving and expanding its properties, such as solubility and mucoadhesiveness, for biomedical applications. Such derivatives can be exploited with good results in a number of biomedical areas, including enhancement of nucleic acid transfection in gene therapy, as well as many other applications aiming to maximize drug delivery and aiding tissue engineering. The aim of this review is to provide an up to date overview of the methods used for derivatizing the chitosan with amino acids and to discuss the characteristics and potential biomedical application of the different amino acid derivatized chitosans described in the literature.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomaterials - Volume 33, Issue 30, October 2012, Pages 7565–7583
نویسندگان
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