Functionalized mesoporous silica-coated magnetic graphene oxide by polyglycerol-g-polycaprolactone with pH-responsive behavior: Designed for targeted and controlled doxorubicin delivery

In the present work a novel multifunctional drug nanocarrier was prepared. Polyglycerol-g-polycaprolactone was grafted on Mesoporous silica-coated magnetic graphene oxide. Doxorubicin, as anticancer drug, was loaded on this carrier. The in vitro drug release showed the controlled pH responsive behavior. At the endosomal pH (pH 5.5) the amount of drug release enhanced. This nanocarrier would have potential application in the tumor therapy owing to its biodegradability, controlled release and pH responsive behavior.