Curcumin-loaded solid lipid particles by PGSS technology

- Solid lipid particles impregnated with curcumin are produced by PGSS.
- Minimum amount of organic solvent is required in the process.
- High drug loading yields are achieved.
- Operating conditions are optimized with respect to particle size and size distribution.
- The effect of DMSO feed in the processed mixtures and of helium in the preparation of the mixtures on particle morphology is discussed.