Observation of liquid solution volume expansion during particle precipitation in the supercritical CO2 antisolvent process

▶ Foerster resonant energy transfer (FRET) spectroscopy is a SAS diagnostics tool. ▶ FRET spectroscopy indicates the onset of volume expansion of liquid solvents. ▶ FRET spectroscopy was applied in quasi-thermodynamic and dynamic study. ▶ The onset of volume expansion may happen before jet break up.