Fractionation of thyme (Thymus vulgaris L.) by supercritical fluid extraction and chromatography

▶ Supercritical fluid extraction (SFE) was employed to obtain an extract from thyme (Thymus vulgaris L.). ▶ Supercritical fluid chromatography at preparative scale (Prep-SFC) was then employed to fractionate the original supercritical extract into three different fractions. ▶ After a preliminary screening, one of the Prep-SFC collected fractions showed a high content in thymol.