Measurement and correlation for solubility of dexibuprofen in different solvents from 263.15 to 293.15 K

The solubilities of dexibuprofen in five solvents including methanol, n-butyl alcohol, isobutyl alcohol, n-amyl alcohol, and n-octyl alcohol were measured in the temperature range 263.15–293.15 K under atmospheric pressure. The results indicate that the solubilities of dexibuprofen in the selected solvents increase with temperature. The experimental data were correlated by the modified Apelblat model which fit well with the experimental data. The dissolution enthalpy and entropy of both rac-ibuprofen and dexibuprofen were predicted. Moreover, the solubility data of both of them were correlated using two local composition models: NRTL 1 and UNIQUAC. It is indicated that for dexibuprofen, the NRTL 1 model can provide more accurate estimations of the solubility in the solvents of methanol, ethanol and n-propyl alcohol, while both NRTL 1 and UNIQUAC models can provide good estimations of the solubility in other solvents. For the rac-ibuprofen, the UNIQUAC model performs better to estimate the solubility in all the solvents.

► We measured the solubility data and correlated them by the modified Apelblat model.
► The dissolution enthalpy and entropy of both rac-ibuprofen and dexibuprofen were predicted.
► The solubility data were correlated using NRTL 1 and UNIQUAC model.
► The ΔHd, ΔSd and ΔGd values were estimated and analyzed.
► We made the distinctions between the models for the (S)-enantiomer and the racemate.