Study on the oscillation dissolved behavior of oxysophocarpine in water

In this paper, the enthalpies of dissolution of oxysophocarpine in water were measured using a RD496-2000 Calvet microcalorimeter at 298.15 K under atmospheric pressure, showing that the dissolution process was an endothermic and exothermic oscillation behavior. A series of thermodynamics functions and the half-life were obtained by thermodynamic and kinetic methods. The results show that this work not only provide a simple method for the determination of the half-life for a drug but also offer a theoretical reference for the clinical application of resveratrol.

► The dissolution enthalpies of oxysophocarpine in water was measured using a RD496-2000 Calvet microcalorimeter.
► The results show that the dissolution process possessed an endothermic and exothermic oscillation behavior.
► A series of thermodynamics functions and half-life period were obtained from thermodynamic and kinetic calculations.