Chronic Cadmium Hepatooxidative in Rats: Treatment with Haruan Fish (Channa striata) Extract

Cadmium is an extremely toxic metal commonly found in industrial workplaces. Cd is unable to generate reactive oxygen species (ROS) directly, but Cd-induced oxidative stress is a common phenomenon observed in multiple studies. Haruan or Snakehead (Channa Striata), is a fresh water snakehead fish indigenous to Kalimantan of Indonesian. The exctract of haruan fillet also known have a protective effect. The aim of this study was to investigate a hepatooxidative in rat exposed to Cd and protective effect of haruan extract. The present study was undertaken to examine the inhibitory effect of the haruan extract on cadmium induced oxidative stress in liver. The levels of MDA and peroxide were assessed by colorimetric method. Significant increases was observed in the levels of MDA and peroxide in Cd treated rats. These levels were significantly decreased in Cd and haruan extract treated rats. It can be concluded from presented results that Cd induced oxidative damage in liver by increased MDA and peroxide level. Our results show that haruan extraxt expressed protective role against toxic influence of Cd in liver.