کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6802483 | 543073 | 2015 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Concordance of Direct and Indirect Measures of Medication Adherence in A Treatment Trial for Cannabis Dependence
ترجمه فارسی عنوان
همبستگی اقدامات مستقیم و غیرمستقیم وابستگی به دارو در دادگاه درمان برای وابستگی قارچ
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کلمات کلیدی
تبعیت، خود گزارش، نشانگر بیولوژیک، دفتر خاطرات پزشکی، نظارت بر سطح مواد مخدر،
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
چکیده انگلیسی
The current study compared adherence rates as measured by two indirect measurement methods (pill count and daily medication diary) to two direct measurement methods (urine riboflavin and serum 6-OH-buspirone level measurement) among participants (n = 109) in a medication treatment trial for cannabis dependence. Pill count and diary data showed high levels of percent agreement and strong kappa coefficients throughout the study. Riboflavin levels indicated lower level of percent in adherence during the study as compared to both pill count and self-report. In the subset of participants with 6-OH-buspirone levels (n = 58), the kappa coefficient also showed low to moderate agreement between the pill count and medication diaries with 6-OH-buspirone levels. In contrast to pill count and medication diaries, adherence as measured by riboflavin and 6-OH-buspirone significantly decreased over time. The findings from this study support previous work demonstrating that pill count and patient self-report of medication taking likely overestimate rates of medication adherence, and may become less reliable as the duration of a clinical trial increases.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Substance Abuse Treatment - Volume 57, October 2015, Pages 70-74
Journal: Journal of Substance Abuse Treatment - Volume 57, October 2015, Pages 70-74
نویسندگان
Aimee L. Pharm.D., Nathaniel L. M.S., Susan C. Pharm.D., C. Lindsay Pharm.D., Amanda M.A., Jessica B.S.,