کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6804152 1433554 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Caloric restriction increases ketone bodies metabolism and preserves blood flow in aging brain
ترجمه فارسی عنوان
محدودیت کالری متابولیسم بدن کتون را افزایش می دهد و جریان خون را در مغز سالم حفظ می کند
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
چکیده انگلیسی
Caloric restriction (CR) has been shown to increase the life span and health span of a broad range of species. However, CR effects on in vivo brain functions are far from explored. In this study, we used multimetric neuroimaging methods to characterize the CR-induced changes of brain metabolic and vascular functions in aging rats. We found that old rats (24 months of age) with CR diet had reduced glucose uptake and lactate concentration, but increased ketone bodies level, compared with the age-matched and young (5 months of age) controls. The shifted metabolism was associated with preserved vascular function: old CR rats also had maintained cerebral blood flow relative to the age-matched controls. When investigating the metabolites in mitochondrial tricarboxylic acid cycle, we found that citrate and α-ketoglutarate were preserved in the old CR rats. We suggest that CR is neuroprotective; ketone bodies, cerebral blood flow, and α-ketoglutarate may play important roles in preserving brain physiology in aging.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Aging - Volume 36, Issue 7, July 2015, Pages 2296-2303
نویسندگان
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