کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6805603 1433565 2014 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Reverse engineering of Alzheimer's disease based on biomarker pathways analysis
ترجمه فارسی عنوان
مهندسی معکوس بیماری آلزایمر بر اساس تجزیه و تحلیل مسیرهای بیومارکر
کلمات کلیدی
بیماری آلزایمر، کم خونی بیومارکرها، تجزیه و تحلیل مسیرها،
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
چکیده انگلیسی
Alzheimer's disease (AD) poses an increasingly profound problem to society, yet progress toward a genuine understanding of the disease remains worryingly slow. Perhaps, the most outstanding problem with the biology of AD is the question of its mechanistic origins, that is, it remains unclear wherein the molecular failures occur that underlie the disease. We demonstrate how molecular biomarkers could help define the nature of AD in terms of the early biochemical events that correlate with disease progression. We use a novel panel of biomolecules that appears in cerebrospinal fluid of AD patients. As changes in the relative abundance of these molecular markers are associated with progression to AD from mild cognitive impairment, we make the assumption that by tracking their origins we can identify the biochemical conditions that predispose their presence and consequently cause the onset of AD. We couple these protein markers with an analysis of a series of genetic factors and together this hypothesis essentially allows us to redefine AD in terms of the molecular pathways that underlie the disease.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Aging - Volume 35, Issue 9, September 2014, Pages 2029-2038
نویسندگان
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